{"id":3048,"date":"2022-07-19T20:26:49","date_gmt":"2022-07-19T20:26:49","guid":{"rendered":"https:\/\/afiyafrica.com\/?p=3048"},"modified":"2022-07-19T20:40:50","modified_gmt":"2022-07-19T20:40:50","slug":"le-sildenafil-vasodilate-mais-remodele-aussi-les-petits-vaisseaux","status":"publish","type":"post","link":"https:\/\/afiyafrica.com\/index.php\/actualite\/le-sildenafil-vasodilate-mais-remodele-aussi-les-petits-vaisseaux\/","title":{"rendered":"Le sild\u00e9nafil vasodilate, mais remod\u00e8le aussi les petits vaisseaux"},"content":{"rendered":"
\n
\n \t<\/i> Read Time:<\/span>2 Minute, 56 Second <\/div>\n\n <\/div>

Le sild\u00e9nafil est un puissant\u00a0vasodilatateur<\/span>\u00a0utilis\u00e9 \u00e0 haute dose dans le traitement de l\u2019hypertension pulmonaire. Une \u00e9quipe Inserm vient de montrer qu\u2019au-del\u00e0 de son action locale, le m\u00e9dicament induit un remodelage des vaisseaux qui accro\u00eet consid\u00e9rablement la densit\u00e9 du r\u00e9seau vasculaire.<\/strong><\/p>\n

Le sild\u00e9nafil est tr\u00e8s connu sous le nom commercial de Viagra\u00ae. Mais cette mol\u00e9cule est utilis\u00e9e dans d\u2019autres indications que la dysfonction \u00e9rectile, en particulier dans le traitement de l\u2019hypertension pulmonaire o\u00f9 elle est administr\u00e9e \u00e0 haute dose. En inhibant une enzyme cellulaire appel\u00e9e PDE5, le sild\u00e9nafil exerce en effet une action vasodilatatrice qui r\u00e9duit la pression art\u00e9rielle au niveau des art\u00e8res pulmonaires. Par ailleurs, son administration est associ\u00e9e \u00e0 l\u2019apparition de nouveaux vaisseaux, constat\u00e9e lors d\u2019examens d\u2019imagerie. \u00ab\u00a0Si le sild\u00e9nafil entra\u00eene la formation locale de nouveaux vaisseaux, que se passe-t-il dans le reste de l\u2019organisme et comment ces vaisseaux se forment-ils\u00a0?<\/em>\u00a0\u00bb, interroge Laurent Loufrani*, qui travaille \u00e0 Angers sur les m\u00e9canismes de l\u2019hypertension et du remodelage vasculaire. Avec son \u00e9quipe, il a voulu mieux comprendre l\u2019impact de ce m\u00e9dicament lorsqu\u2019il est utilis\u00e9 \u00e0 haute\u00a0dose.<\/p>\n

Les chercheurs ont pour cela travaill\u00e9 chez le rat, dans un contexte exp\u00e9rimental qui permet de \u00ab\u00a0forcer\u00a0\u00bb la formation de nouveaux vaisseaux\u00a0: l\u2019obstruction d\u2019une art\u00e8re (isch\u00e9mie<\/span>). Concr\u00e8tement, ils ont ligatur\u00e9 une art\u00e8re de la cuisse gauche des animaux, puis administr\u00e9 du sild\u00e9nafil \u00e0 haute dose \u00e0 une partie d\u2019entre eux, pendant 7 ou 21 jours. Ils ont ensuite analys\u00e9 les vaisseaux des rats des diff\u00e9rents groupes, notamment pour identifier la provenance des cellules pr\u00e9sentes dans les vaisseaux nouvellement form\u00e9s.<\/p>\n

Un r\u00e9seau pr\u00e9existant \u00e9toff\u00e9<\/h2>\n

Les chercheurs ont observ\u00e9 une densification du r\u00e9seau vasculaire dans la zone de l\u2019isch\u00e9mie, chez tous les animaux. Mais le ph\u00e9nom\u00e8ne \u00e9tait beaucoup plus intense chez les rats qui avaient re\u00e7u du sild\u00e9nafil. Le r\u00e9seau \u00e9tait 50\u00a0% plus important apr\u00e8s 7 jours de traitement et sa densit\u00e9 avait m\u00eame doubl\u00e9 au bout de trois semaines. Il \u00e9tait \u00e9galement plus important dans des zones distantes de l\u2019art\u00e8re exp\u00e9rimentalement obstru\u00e9e, notamment au niveau des art\u00e8res m\u00e9sent\u00e9riques (branches de l\u2019aorte abdominale).<\/p>\n

Pour savoir si ce ph\u00e9nom\u00e8ne \u00e9tait li\u00e9 \u00e0 l\u2019apparition de vaisseaux nouvellement form\u00e9s ou s\u2019il s\u2019agissait de petits vaisseaux remodel\u00e9s et devenus plus importants, les chercheurs ont administr\u00e9 des\u00a0anticorps<\/span>\u00a0qui bloquent la formation de nouveaux vaisseaux \u00e0 certains des animaux qui recevaient du sild\u00e9nafil. R\u00e9sultat\u00a0: ce traitement n\u2019a pas emp\u00each\u00e9 l\u2019augmentation de la densit\u00e9 vasculaire sous sild\u00e9nafil. \u00ab\u00a0Nous avons ainsi la d\u00e9monstration du fait que le r\u00e9seau vasculaire s\u2019\u00e9toffe gr\u00e2ce au remodelage de vaisseaux pr\u00e9existants. Leur diam\u00e8tre s\u2019accro\u00eet, leur paroi s\u2019\u00e9paissit, et ils peuvent absorber un plus gros d\u00e9bit sanguin<\/em>\u00a0\u00bb, explique le chercheur.<\/p>\n

Ce travail permet de mieux comprendre le mode d\u2019action du sild\u00e9nafil. Il montre comment la mol\u00e9cule modifie le r\u00e9seau vasculaire d\u00e9j\u00e0 existant, au-del\u00e0 de son action vasodilatatrice. \u00ab\u00a0Il appara\u00eet que le syst\u00e8me vasculaire se trouve consid\u00e9rablement modifi\u00e9 par le sild\u00e9nafil, dans sa globalit\u00e9. Si ces observations ne remettent absolument pas en cause l\u2019utilisation de ce m\u00e9dicament, elles objectivent des changements qu\u2019il induit \u00e0 long terme dans l\u2019organisme et qu\u2019il est important de conna\u00eetre<\/em>\u00a0\u00bb, conclut-il.<\/p>\n

Note\u00a0<\/strong>:
\n* unit\u00e9 1083 Inserm\/CNRS\/Angers Universit\u00e9, MITOVASC,\u00a0\u00e9quipe CarMe<\/i><\/a><\/p>\n

Source\u00a0<\/strong>: C. Baron-Menguy et coll. Sildenafil-Induced Revascularization of Rat Hindlimb Involves Arteriogenesis through PI3K\/AKT and eNOS Activation.\u00a0Int J Mol Sci<\/em>\u00a0du 16 mai 2022. Doi\u00a0:\u00a010.3390\/ijms23105542<\/i><\/a>.<\/p>\n

source : INSERM<\/p>\n

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Le sild\u00e9nafil est un puissant\u00a0vasodilatateur\u00a0utilis\u00e9 \u00e0 haute dose dans le traitement de l\u2019hypertension pulmonaire. Une…<\/p>\n","protected":false},"author":1,"featured_media":3049,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[12],"tags":[60,688,690],"class_list":["post-3048","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualite","tag-afrique-sante","tag-hypertension-pulmonaire","tag-sildenafil"],"yoast_head":"\nLe sild\u00e9nafil vasodilate, mais remod\u00e8le aussi les petits vaisseaux -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/afiyafrica.com\/index.php\/actualite\/le-sildenafil-vasodilate-mais-remodele-aussi-les-petits-vaisseaux\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Le sild\u00e9nafil vasodilate, mais remod\u00e8le aussi les petits vaisseaux -\" \/>\n<meta property=\"og:description\" content=\"Le sild\u00e9nafil est un puissant\u00a0vasodilatateur\u00a0utilis\u00e9 \u00e0 haute dose dans le traitement de l\u2019hypertension pulmonaire. 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