{"id":2621,"date":"2022-06-24T20:01:04","date_gmt":"2022-06-24T20:01:04","guid":{"rendered":"http:\/\/afiyafrica.com\/?p=2621"},"modified":"2022-06-24T20:24:36","modified_gmt":"2022-06-24T20:24:36","slug":"au-congo-le-sequencage-genomique-de-la-covid-19-au-service-dautres-maladies","status":"publish","type":"post","link":"https:\/\/afiyafrica.com\/index.php\/actualite\/au-congo-le-sequencage-genomique-de-la-covid-19-au-service-dautres-maladies\/","title":{"rendered":"Au Congo, le s\u00e9quen\u00e7age g\u00e9nomique de la COVID-19 au service d\u2019autres maladies"},"content":{"rendered":"
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\n \t<\/i> Read Time:<\/span>4 Minute, 26 Second <\/div>\n\n <\/div>
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Le Laboratoire national de sant\u00e9 publique devrait aussi prochainement b\u00e9n\u00e9ficier d\u2019un soutien de la Banque mondiale afin de d\u00e9velopper ses propres capacit\u00e9s de s\u00e9quen\u00e7age g\u00e9nomique<\/strong><\/p>\n

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\u00ab\u00a0Gr\u00e2ce au s\u00e9quen\u00e7age g\u00e9nomique, les autorit\u00e9s sont inform\u00e9es quasi imm\u00e9diatement de la circulation de variants de la COVID-19\u00a0dans le pays \u00bb<\/strong><\/em>, explique la professeure Francine Ntoumi, pr\u00e9sidente de la Fondation congolaise pour la recherche m\u00e9dicale (FCRM), bas\u00e9e dans la capitale Brazzaville. \u00ab\u00a0D\u00e9sormais, nous voulons utiliser ces capacit\u00e9s de s\u00e9quen\u00e7age pour surveiller d\u2019autres pathologies.\u00a0\u00bb<\/strong><\/em><\/p>\n

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Deux ans apr\u00e8s le d\u00e9but de la pand\u00e9mie, la R\u00e9publique du Congo commence en effet \u00e0 mettre ses capacit\u00e9s de s\u00e9quen\u00e7age g\u00e9nomique d\u00e9velopp\u00e9es pour lutter contre la COVID-19 au service de la surveillance d\u2019autres pathog\u00e8nes, comme ceux responsables du paludisme, de la tuberculose ou de maladies diarrh\u00e9iques chez les jeunes enfants.<\/p>\n

Un protocole de s\u00e9quen\u00e7age a d\u00e9j\u00e0 \u00e9t\u00e9 \u00e9tabli par la FCRM pour d\u00e9crire les g\u00e8nes du staphylocoque responsables de la r\u00e9sistance de la bact\u00e9rie aux antibiotiques, ce qui permettra de mieux soigner les patients. \u00ab\u00a0Nous devrions avoir un \u00e9chantillonnage suffisamment significatif d\u2019ici la fin de l\u2019ann\u00e9e. Nous pourrons alors adapter les traitements afin de contourner cette r\u00e9sistance\u00a0\u00bb<\/strong><\/em>, se r\u00e9jouit le Dr Armel Btachi Boyou, m\u00e9decin chercheur \u00e0 la Fondation et \u00e0 la clinique municipale Albert Leyono, le centre sp\u00e9cialis\u00e9 dans la prise en charge des cas graves COVID-19 \u00e0 Brazzaville. Cette m\u00eame approche sera ensuite \u00e9galement appliqu\u00e9e \u00e0 une batterie de parasites responsables de maladies r\u00e9pandues au Congo.<\/p>\n

\u00ab\u00a0Le d\u00e9veloppement du s\u00e9quen\u00e7age g\u00e9nomique au Congo a mis en lumi\u00e8re l\u2019importance de la recherche, de disposer de laboratoires en biologie mol\u00e9culaire et d\u2019un personnel form\u00e9, pour lutter efficacement contre les maladies\u00a0\u00bb<\/strong><\/em>, souligne la professeure Francine Ntoumi. Le pays produit d\u00e9sormais ses propres s\u00e9quences g\u00e9nomiques du virus \u00e0 l\u2019origine de la COVID-19, alors qu\u2019auparavant les \u00e9chantillons \u00e9taient envoy\u00e9s \u00e0 l\u2019\u00e9tranger, ce qui \u00e9tait long et parfois co\u00fbteux. \u00ab\u00a0Surtout, nous obtenons maintenant des r\u00e9sultats en temps r\u00e9el . Nous pouvons ainsi d\u00e9crire la situation chez nous, sans extrapoler en fonction de ce qui se passe ailleurs et les autorit\u00e9s peuvent prendre des d\u00e9cisions bas\u00e9es sur l\u2019\u00e9vidence locale\u00a0\u00bb<\/strong><\/em>, constate la scientifique.<\/p>\n

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Gr\u00e2ce au s\u00e9quen\u00e7age g\u00e9nomique, les autorit\u00e9s sont inform\u00e9es quasi imm\u00e9diatement de la circulation de variants de la COVID-19 dans le pays<\/p><\/blockquote>\n<\/div>\n

Entre 2020 et 2022, la Fondation congolaise pour la recherche m\u00e9dicale, seul organisme poss\u00e9dant des capacit\u00e9s de s\u00e9quen\u00e7age en R\u00e9publique du Congo, a multipli\u00e9 par quatre sa capacit\u00e9 s\u00e9quen\u00e7age quotidienne, passant de 24 \u00e0 96 s\u00e9quences g\u00e9nomiques par jour. Une collaboration avec l\u2019ambassade d\u2019Allemagne en R\u00e9publique du Congo a permis \u00e0 la FCPM de mettre son mat\u00e9riel aux normes, d\u2019acqu\u00e9rir des r\u00e9actifs n\u00e9cessaires au s\u00e9quen\u00e7age g\u00e9nomique et d\u2019envoyer deux de ses sept chercheurs \u00a0suivre une formation de trois mois \u00e0 l\u2019universit\u00e9 de T\u00fcbingen, fin 2021. L\u2019\u00e9quipement dont disposait la fondation a pu ensuite \u00eatre exploit\u00e9 au maximum, ce qui n\u2019\u00e9tait pas le cas auparavant, faute de personnel form\u00e9.<\/p>\n

Pendant les deux premi\u00e8res ann\u00e9es de la pand\u00e9mie de COVID-19, les informations fournies par le s\u00e9quen\u00e7age g\u00e9nomique des variants en circulation dans le pays ont ainsi aid\u00e9 les responsables politiques \u00e0 comprendre la circulation des variants, \u00e0 adapter les mesures de riposte en fonction de leur contagiosit\u00e9 et \u00e0 anticiper les vagues d\u2019infections.<\/p>\n

\u00ab\u00a0En permettant de conna\u00eetre les variants qui circulent, le s\u00e9quen\u00e7age offre la possibilit\u00e9 d\u2019une riposte pr\u00e9cise et d\u2019optimiser l\u2019utilisation des ressources, ce qui est primordial pour des pays o\u00f9 ces ressources sont limit\u00e9es\u00a0\u00bb<\/strong><\/em>, confirme le Dr Gilbert Ndziessi, Coordonnateur technique du Comit\u00e9 national de riposte \u00e0 la COVID-19, mis en place par le Minist\u00e8re de la Sant\u00e9. \u00ab\u00a0Lorsque le variant Delta, plus l\u00e9tal que les autres, a \u00e9t\u00e9 d\u00e9tect\u00e9 au Congo, nous avons orient\u00e9 nos activit\u00e9s de riposte vers les h\u00f4pitaux pour une prise en charge optimale des patients. Avec le variant Omicron, nous nous sommes concentr\u00e9s sur le travail de sensibilisation aupr\u00e8s des communaut\u00e9s.\u00a0\u00bb<\/strong><\/em><\/p>\n

Les capacit\u00e9s de s\u00e9quen\u00e7age g\u00e9nomique du pays ont encore besoin d\u2019\u00eatre d\u00e9velopp\u00e9es et il arrive que les r\u00e9actifs n\u00e9cessaires au s\u00e9quen\u00e7age des \u00e9chantillons ne soient pas toujours disponibles. \u00ab\u00a0Il est vrai que nos capacit\u00e9s de s\u00e9quen\u00e7age restent limit\u00e9es, mais elles sont suffisamment significatives pour savoir quels variants circulent et lesquels sont majoritaires\u00a0dans le pays ainsi que ceux infectant nos patients\u00bb<\/strong><\/em>, nuance le Dr Armel Batchi Boyou, l\u2019un des deux scientifiques form\u00e9s au s\u00e9quen\u00e7age en Allemagne.<\/p>\n

Par ailleurs, le Laboratoire national de sant\u00e9 publique devrait aussi prochainement b\u00e9n\u00e9ficier d\u2019un soutien de la Banque mondiale afin de d\u00e9velopper ses propres capacit\u00e9s de s\u00e9quen\u00e7age g\u00e9nomique.<\/p>\n

Soutenu par l\u2019Organisation mondiale de la Sant\u00e9 (OMS), la FCRM met actuellement en \u0153uvre un projet de renforcement des capacit\u00e9s nationales en termes d\u2019essais cliniques, avec pour objectif de pr\u00e9parer le terrain \u00e0 l\u2019introduction des nouveaux traitements contre la COVID-19.<\/p>\n

\u00ab\u00a0Le renforcement des capacit\u00e9s de s\u00e9quen\u00e7age g\u00e9nomique participe \u00e0 divers niveaux \u00e0 l\u2019autonomisation du pays en termes de surveillance des maladies et de prise en charge des patients, donc de lutte contre les \u00e9pid\u00e9mies\u00a0\u00bb<\/strong><\/em>, souligne le Dr Lucien Manga, Repr\u00e9sentant de l\u2019OMS en R\u00e9publique du Congo. Depuis 2020, l\u2019OMS accompagne la FCRM dans les actions de surveillance g\u00e9nomique et de renforcement des capacit\u00e9s nationales, et nous sommes heureux de cette importante collaboration \u00bb.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Le Laboratoire national de sant\u00e9 publique devrait aussi prochainement b\u00e9n\u00e9ficier d\u2019un soutien de la Banque…<\/p>\n","protected":false},"author":1,"featured_media":2622,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[12,39],"tags":[31,112,32,120,62],"class_list":["post-2621","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualite","category-congo","tag-afrique","tag-covid-19","tag-oms","tag-oms-afrique","tag-sante-en-afrique"],"yoast_head":"\nAu Congo, le s\u00e9quen\u00e7age g\u00e9nomique de la COVID-19 au service d\u2019autres maladies -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link 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